Thanks to the rapid development of high-throughput sequencing technologies, we can currently investigate those molecular markers of clinical and prognostic significance through bioinformatics studies [18].In this study, the analysis of the TCGA database has obtained the analysis of MFN2 expression in ccRCC and its prognostic role in OS, and further analyzed the correlation of MFN2 expression with methylation and immunity.This study helps to provide new therapeutic ideas and methods for the therapy of clear cell renal cell carcinoma. Here, MFN2 is linked to clear cell renal carcinoma.