CDKN2A and neoplasm: Ghobadi and colleagues 2019, after examining the relationship between rs10811661 and rs1333049 polymorphisms in chromosome 9 P21 locus in CDKN2A / B gene, patients with esophageal squamous cell carcinoma (ESCC) and healthy individuals concluded that in patients with carcinoma cancer, Esophageal squamous cells had a higher frequency of TT genotype for rs10811661 polymorphism than the control group and tumor size was reported to be larger in affected individuals.