CDKN2A and breast cancer: Hesari et al. 2018, in research on the 2 polymorphisms of rs1801133 in methylene tetrahydrofolate reductase and rs10811661 in CDKN2A / B in patients with breast cancers, concluded that the frequency of T allele and TT genotype in methylene tetrahydrofolate reductase gene was more prevalent in patients than in the control group.