MNP-2 cells also exhibit more stem-like features28 with enrichment of naive TFs (for example, LEF1), distinguishing them from other types of unconventional CD8+ T cells described in adults that expand during chronic viral infection, acute infection and/or autoimmunity and exhibit distinct phenotypes (for example, terminally differentiated, regulatory)29–31. The gene discussed is LEF1; the disease is Autoimmunity.