Afterwards, we examined the expression of PHF5A according to N staging and discovered a significant association of lymph node metastasis with PHF5A expression in 6 types of cancer: ACC, COAD, Colon adenocarcinoma/Rectum adenocarcinoma esophageal carcinoma (COADREAD), HNSC, LUAD, and Stomach and esophageal carcinoma (STES) (Fig. 2D). Here, PHF5A is linked to colon adenocarcinoma.