Since both Mesothelioma (MESO) and Uveal melanoma (UVM) also lack corresponding normal tissue data in the GTEx database, these two cancer types were not included or compared in Fig. 1B. For paired tumor and paracancerous tissues, aside from some tumors lacking paired data, PHF5A demonstrated high expression levels in BLCA, BRCA, CHOL, COAD, ESCA, HNSC, Kidney renal clear cell carcinoma (KIRC), LIHC, LUAD, LUSC and STAD (Fig. 1C). The gene discussed is PHF5A; the disease is cancer.