APOB and cardiovascular disorder: Based on follow-up network analysis (Methods) using PheWAS summary statistics, we identified seven distinct modules of phenotype clusters (Fig. 5a and Supplementary Tables 18 and 19) representing low-density lipoprotein (LDL) cholesterol, apolipoprotein B, coronary heart disease, anthropometric traits, apolipoprotein A/metabolic biomarkers, blood cell traits and total cholesterol/cardiovascular disease medications.