APOA1 and triple-A syndrome: We first performed conventional inverse-variance weighted MR, finding associations between each major lipoprotein-related trait (nonhigh-density lipoprotein cholesterol (non-HDL-C), LDL cholesterol (LDL-C), HDL-C, triglycerides, ApoA1, and ApoB) and AAA (Supplementary Fig. 15, Supplementary Tables 21 and, 22 and Supplementary Note).