LGR5 and neoplasm: Nevertheless, consistent with our mechanistic findings, tumor organoids derived from an Apcmin/− mouse model lacking Bmal1 (Apcmin/−; Bmal1−/−) found that both Lgr5 and Mex3a were significantly downregulated compared to organoids derived from Apcmin/−; Bmal+/+ tumors51 indicating that Lgr5 and Mex3a are regulated by BMAL1.