FBN1 and progeroid and marfanoid aspect-lipodystrophy syndrome: Marfanoid-progeroid-lipodystrophy syndrome (MFLS, MIM #616914)1 is caused by heterozygous variants affecting exon 65 near the 3’ terminus of the FBN1 gene, which is known as one of the causative genes for Marfan syndrome.