FBN1 and progeroid and marfanoid aspect-lipodystrophy syndrome: MFLS is an extremely rare medical condition caused by heterozygous pathogenic variants in the FBN1 gene, with characteristic clinical manifestations of severe partial lipodystrophy, premature birth with accelerated linear growth disproportionate to weight gain, and a progeroid appearance with distinct facial features, as well as a variety of clinical manifestations partially overlapping with Marfan syndrome1–4.