MAPT and Alzheimer disease: Specifically, the tendency of higher Tau aggregate accumulation in women has also been reported for other neurodegenerative diseases, such as AD [66], which may result from sex differences in microglia networks and age-dependent loss (for example, in AD [67] and PSP [68]).The surprising sex differences in PSP led to the discovery of the significant clinical efficacy of davunetide in women, correcting the initial assumption of sex similarity in PSP disease progression [28].