ADNP and supranuclear palsy, progressive, 1: Additionally, the PSP female patient brain reacted differently to davunetide treatment than did the PSP male brain, as seen by the age- and baseline volume-dependent manners of response, which require neuroprotection, with davunetide treatment protecting microtubule-actin interactions [6], brain structure [51], and axonal transport [27], regulated by ADNP in a sex-dependent manner [2].