FLNA and supranuclear palsy, progressive, 1: The filamin A previous findings, coupled with estrogen-mediated regulation of alternative splicing [34], misbalances in 4R and 3R Tau levels leading to differences in axonal transport [50], and the higher susceptibility of microtubules in the female brain to neurodegeneration [14] may explain the vulnerability of the female PSP brain and the significant differences seen, relative to males.