VWF and von Willebrand disease (hereditary or acquired): VWD results from heterozygous, homozygous or compound heterozygous variants in the VWF. We found that of 141,456 individuals in the gnomAD population 1026 (0.72%) were homozygotes for different VWF variants, with 29,733 (21%) apparently heterozygotes and 110,697 (78.3%) wild type.