Following a conservative approach to classify variants as pathogenic (i.e., as responsible for VWD), we found 505 distinct VWF deleterious variants of which 287 (57%) have not been reported to be associated with VWD in the literature nor in VWD-related databases (Supplementary Table 1), whereas 218 (43%) had been already reported (Supplementary Table 2). This evidence concerns the gene VWF and von Willebrand disease (hereditary or acquired).