CDKN2A and colorectal carcinoma: To confirm that TNFα induces CDKN2A expression in human colonic cells, we used CRC organoids (CRC20) carrying mutations in APC but wt for TP53 and KRAS, and normal cecum epithelial organoids (Ce) and confirmed the induction of p14 by TNFα in both cell types (Fig. 4n, o).