KRAS and cancer: Considering that KRAS frequently drives the pancreas, colon, lung, and other cancers70, E3 ligases were expected to be highly expressed in these cancer types and also interact with KRAS. We identified several potentially novel E3 ligases, such as F-Box Protein 22 (FBXO22) and Protein Regulator Of Cytokinesis 1 (PRC1), that were highly expressed in multiple cancer types, but lowly expressed in most normal tissues, may serve as good candidates for high expression in above-mentioned cancer types (Supplementary Fig. 16).