As expected, SPRY2 knockdown significantly recovered the decreased proliferation (Fig. 9D) and invasion of the cells (Fig. 9E), and increased P-ERK expression (Fig. 9F) and CD133+ stem cell subpopulations (Fig. 9G) in PCa cells resulting from HOXA5 overexpression. The gene discussed is SPRY2; the disease is posterior cortical atrophy.