MDM2 and cancer: Therefore, our findings suggest that ACP52C can induce apoptosis via MDM2 p90 downregulation in i) wildtype p53‐bearing cancers through p53 upregulation and phosphorylation, ii) p53‐null cancers through p63 and p73 upregulation, and iii) mutant p53‐bearing cancers through p63 and p73 upregulation.