As a driving force behind massive DNA DSBs and the induction of DDR in ACP52C‐mediated cancer‐specific apoptosis, we identified TDP2 (also known as TTRAP or EAPII).[24] This identification was made through yeast two‐hybrid assays[7a] as well as confirmed by in vivo co‐IP analyses (Figure 5E; Figure S16A, Supporting Information). Here, TDP2 is linked to cancer.