For patients with HLA-DRB1*03/15 +/+, we also found that prevalence of low complement levels, defined according to SLICC-12 criteria,24 was higher in patients with a high SLE B cell PRS (83%), compared with patients with low PRS (56%) (OR 3.92 (1.22 to 12.64), p=0.022) (online supplemental table 1). The gene discussed is HLA-DRB1; the disease is systemic lupus erythematosus.