In the current study, we aimed to investigate associations between SLE PRSs with genes limited to B cell function, autoantibody production, complement levels and organ manifestations, as well as the significance of high PRS in patients with HLA risk variants HLA-DRB1*03:01 and HLA-DRB1*15:01. This evidence concerns the gene HLA-DRB1 and systemic lupus erythematosus.