Dysregulatedcytokine production can increase cancer metastasis through a varietyof mechanisms including angiogenesis, matrix remodeling, cell proliferation,and cell migration.114 TNF-α canalter membrane lipid composition115 andincrease adhesion through both the upregulation of cell surface ligands116−119 and the activation of integrins by inside-out signaling.119,120 The increased uptake of L-Ki16425 in TNF-α-treated 4T1 cellsmay be attributed to the changes in cell membrane mechanics, increasedadhesion, or changes in protein expression. This evidence concerns the gene TNF and cancer.