In univariate analysis of OS, tumor diameter > 4 cm (Fig. 2A; p = 0.013), LVSI (Fig. 2B; p < 0.001), the presence of LS (Fig. 2C; p = 0.019), negative p16 expression (Fig. 2D; p = 0.007), aberrant p53 expression (Fig. 2E; p = 0.012), negative HPV status (Fig. 2F; p = 0.021), lymph node metastasis (yes vs. no and 0 vs. 1 vs. > 1, Fig. 2G and H, respectively; both p < 0.001) and post-operative radiotherapy (Fig. 2I; p < 0.001) were significantly related to shorter OS. The gene discussed is TP53; the disease is neoplasm.