In contrast, lack of Gαi2 was clearly detrimental in previous studies, either in the same heart-failure model of β1-AR overexpression, a model of β2-AR overexpression or with ischemia–reperfusion as pathophysiological stimulus (Foerster et al. 2003; Köhler et al. 2014; Keller et al. 2015). Here, ADRB2 is linked to heart failure.