The results showed that DAPT treatment did not reduce the liver/BW ratio, the percentage of Ki67+ cells,or tumor numbers in Numb Ww45Δhep livers, in which protein levels of NICD and mRNA levels of the Notch target genes Hes1 and Hey1 were dramatically decreased, while mRNA levels of the YAP target genes Ctgf and Cyr61 were unchanged after DAPT treatment (Supplemental Figure 15, A–F). Here, HES1 is linked to neoplasm.