NUMB and hepatocellular carcinoma: Interestingly, regardless of the high or low expression levels of NUMB, we detected increased cytoplasmic localization of NUMB along with YAP nuclear retention during HCC progression as compared with adjacent normal tissues, in which YAP was distributed in the cytoplasm and NUMB was exclusively located on the plasma membrane (Figures 10C and Supplemental Figure 17A).