NUMB and neoplasm: Similar to Numb gene deletion, CRISPR/Cas9-mediated Sptan1 gene deletion in WT mice did not alter liver size, liver/BW ratios, or liver tumor formation, whereas deletion of Sptan1 in Ww45ΔHep mice remarkably promoted liver enlargement, tumor formation, and YAP activation (Supplemental Figure 13, A–D).