Notably, we observed robust reduction of WW45 (i.e., ratios of T/N <0.5; 53 of 60) and dramatically increased MARK2 (i.e., ratios of T/N >2), especially among WW45-low tumor tissues (38 of 53) (Figures 10A and Supplemental Figure 16B). The gene discussed is MARK2; the disease is neoplasm.