NUMB and neoplasm: However, the variation in NUMB protein levels in tumor tissues, whether higher or lower, was irregular compared with levels in the paired, adjacent nontumorous tissues, as the results showed that 22 of 60 patients had higher expression levels NUMB (ratios of T/N >2) and that 19 of 60 patients had lower expression levels of NUMB (ratios of T/N <0.5) in tumor tissues than levels detected in adjacent nontumorous tissues (Figure 10B).