In the case of TRAIL‐resistant cells HT‐29, rNDV‐TRAIL infection strongly activated caspases‐8, ‐9, and ‐3 as well as the release of cytochrome c from mitochondria, surpassing the effects of rNDV infection alone I. The enhanced expression of DRs, along with theirincreased interaction with TRAIL protein, activated the extrinsic apoptotic pathway. The gene discussed is CYCS; the disease is infection.