These results showed the smallest tumor masses were observed in the rNDV‐TRAIL group (301.0 and 373.8 mm3), compared to the rNDV (533.7 and 685.6 mm3) or PBS (1059.3 and 1069.6 mm3) groups in both HCT116 and HT‐29 xenograft mice at 17 days postinjection. This evidence concerns the gene TNFSF10 and neoplasm.