PHD2 in particular appears to have an important role – multiple groups have demonstrated that mice with endothelial cell-specific PHD2 deletion develop spontaneous pulmonary hypertension (Dai et al., 2016; Elamaa et al., 2022; Kapitsinou et al., 2016; Tang et al., 2018; Wang et al., 2016). The gene discussed is EGLN1; the disease is pulmonary hypertension.