TF and cancer: To showcase the value of using CollecTRI-derived regulons for predicting TF activities, we performed a TF activity inference analysis using differential expression data from three cancer types: Uterine Corpus Endometrial Carcinoma (UCEC) (64), Lung Adenocarcinoma (LUAD) (65) and Clear Cell Renal Cell Carcinoma (CCRCC) (66) (Figure 3A).