Differentially expressed genes from Prdm16csp1/wt hearts (TOP5 up- and down-regulated genes) and known PRDM16 interacting genes (physical interaction, transcriptional targets, transcriptional complex component) were tested for dysregulation in a dataset obtained from human DCM patients.21 From over 60 known PRDM16 targets, we found that PPARA, MED1, and CEBPD were dysregulated in the human DCM screen (see Supplementary material online, Table SVII in the Data Supplement). Here, MED1 is linked to familial dilated cardiomyopathy.