Originally, the cytogenetic association of PRDM16 inactivation with cardiomyopathy was described in 18 patients with 1p36 syndrome.4 Among these, 16 individuals were females and only two were males.4 This may point to a sex-specific penetrance of the PRDM16 cardiomyopathy. This evidence concerns the gene PRDM16 and cardiomyopathy.