AKT1 and neoplasm: By comparing the methylome and transcriptome of P. micra-negative versus -positive patients, we observed differentially methylated regions in several other TSGs, oncogenes, or genes involved in EMT, together with significant enrichment of DEGs involved in cell adhesion, regulation of cytoskeleton, and PI3K-Akt signaling that promotes cell-cycle progression, cell survival, migration, and tumor progression.