1) Upregulating the expression of HMGB1 to activate the TLR4/NF-κB pathway through binding to miR-181a-5p, thereby facilitating the M1 polarization of macrophages, ultimately promoting the occurrence and progression of AP. 2) Increasing the levels of IL-6 and TNF-α by regulating the Hippo-YAP signaling pathway. Here, TNF is linked to alkaline phosphatase measurement.