In AP, Liu et al. (2021) found that EV-encapsulated lncRNA MALAT1 could upregulate the expression of HMGB1 and activate the TLR4/NF-κB pathway through binding to miR-181a-5p, thereby facilitating the M1 polarization of macrophages, ultimately promoting the occurrence and progression of AP. This evidence concerns the gene MALAT1 and alkaline phosphatase measurement.