Zhao et al. (2019) reported that LncRNA Fendrr was also upregulated in AP and promoted AR42J cell apoptosis by directly binding the annexin A2 protein. The annexin A2 protein is a calcium-dependent phospholipid-binding protein that participates in multiple biological processes, such as signal transduction, DNA synthesis, cell proliferation, and apoptosis (Vedeler et al., 2012; Chu et al., 2013), and it was suggested that lncRNAs play an important role in acinar cells death. This evidence concerns the gene ANXA2 and alkaline phosphatase measurement.