RUNX3 and neoplasm: Another enriched pathway was RUNX3 Regulates Immune Response and Cell Migration, which suggests that the combination treatment was able to improve anti-tumor immunity by reducing the population of immunosuppressive cell types since RUNX3 is associated with the regulation of inflammatory cells and the generation of Treg cells in the tumor microenvironment (Li et al., 2012; Manandhar and Lee, 2018).