IL27 and neoplasm: The anti-tumor effects of IL-27 gene therapy have been demonstrated before in subcutaneous tumor models (Di Carlo et al., 2014; Figueiredo et al., 2020), however, the more-clinically-relevant intratibial models tend to display far more aggressive growth in the bone (Dai et al., 2014) microenvironment in our laboratory’s experience, making this model much more challenging to treat.