Figure 4H further elucidates that the prognostic risk factors for ESCC patients are eight specific model genes: Proline Rich 13 (PRR13), SH2 Domain Containing 2A (SH2D2A), Thymosin Beta 4 X-Linked (TMSB4X), TSC22 Domain Family, Member 3 (TSC22D3), Phosphoinositide-3-Kinase Interacting Protein 1 (PIK3IP1), Coatomer Protein Complex Subunit Epsilon (COPE), TERF2 Interacting Protein (TERF2IP), and DAZ Associated Protein 2 (DAZAP2). The gene discussed is COPE; the disease is esophageal squamous cell carcinoma.