Upon ligand ligation with respective CLR, these ITAMs recruit syk kinase that subsequently induces a downstream signaling cascade activating caspase-recruitment domain protein 9–B cell lymphoma/leukemia 10–mucosa-associated lymphoid tissue lymphoma translocation protein 1 (CARD-9/BCL-10/MALT-1) complex through protein kinase C-δ (PKCδ). The gene discussed is CARD9; the disease is B-cell non-Hodgkin lymphoma.