TLR4 and tuberculosis: The heparin-binding hemagglutinin (HBHA) of Mtb that serves as a diagnostic parameter of tuberculosis disease imparts strong immunostimulatory effect through TLR4-dependent signaling resulting in DC maturation, activation of simple T cells, the polarization of T cells in order to produce IFN-γ, as well as subsequent cytotoxic T cell-mediated toxicity [57].