CHF - congestive heart failure; CAD - coronary artery disease; HFpEF - heart failure with preserved ejection fraction; MACE - major adverse cardiovascular events; AHF - acute heart failure; ROS - reactive oxygen species; XO - xanthine oxidase; HFrEF - heart failure with reduced ejection fraction; LVEF - left ventricular ejection fraction. Here, XDH is linked to congestive heart failure.