By ROC curve analysis, renin showed moderate ability in discriminating AKI (AUC, 0.72; 95%CI, 0.63-0.81) (Figure 2A) and strong ability to predict mortality in children with SCD (AUC, 0.94; 95%CI, 0.89-0.99) (Figure 2B). Here, REN is linked to acute kidney injury.