In our study, we found tissue localization of HIF-1α is mostly in cytoplasmic + nuclear in well-differentiated carcinoma and cytoplasmic in moderately differentiated carcinoma which was statistically significant, and HIF-2α expression was mostly seen in cytoplasmic in well-differentiated and nuclear in both moderately and poorly differentiated OSCC [10,13]. The gene discussed is HIF1A; the disease is carcinoma.