DPP4 is considered an adipokine with a pleiotropic effect, whose levels are increased in conditions of obesity, insulin resistance and T2DM; it is also involved in lipid metabolism and in the atherosclerotic process.DPP4-i include sitagliptin, alogliptin, linagliptin and saxagliptin. The gene discussed is DPP4; the disease is obesity due to melanocortin 4 receptor deficiency.