DPP4 is considered an adipokine with a pleiotropic effect, whose levels are increased in conditions of obesity, insulin resistance and T2DM; it is also involved in lipid metabolism and in the atherosclerotic process.DPP4-i include sitagliptin, alogliptin, linagliptin and saxagliptin. This evidence concerns the gene DPP4 and type 2 diabetes mellitus.