NO also contributes to matrix remodeling, neovascularization, tumor growth, and local and distant thyroid malignancy spreading by affecting tissue inhibitors of metalloproteinase (TIMP), matrix metallopeptidases (MMP), vascular endothelial growth factor D (VEGF-D), and C-X-C chemokine receptor type 4 (CXCR4) (26–28). This evidence concerns the gene CXCR4 and thyroid gland disorder.