Biomarkers, such as thyroglobulin (TG), anti-thyroglobulin antibodies (ATGAbs), and calcitonin (CT), are routinely used in preoperative diagnosis and postoperative follow-up of patients with TN, DTC, and medullary thyroid cancer (MTC) (19, 20). The gene discussed is CALCA; the disease is medullary thyroid gland carcinoma.