While anti-PD-1 treatment alone in mouse colorectal carcinoma tumors did not significantly alter tumor volume or CD8+ T cell infiltration, depletion of YTHDF1 or restricting methionine in the diet synergized with anti-PD-1 treatment to significantly increase survival probability and CD8+ T cell infiltration, while decreasing tumor volume[202]. This evidence concerns the gene CD8A and colorectal carcinoma.