SCD1 catalyzes the formation of monounsaturated fatty acids (MUFAs), specifically oleate and palmitoleate. Inhibition of SCD1 causes iron-mediated lipid peroxidation and mitochondrial dysfunction by downregulating GPX4 and then induces ovarian cancer cell death. SCD1 inhibitor co-treatment may enhance the antitumor efficacy of ferroptosis inducers in ovarian cancer. Here, GPX4 is linked to ovarian cancer.