These mechanisms include (1) reduced expression of antigens and MHC molecules on the cell surface of AML cells; (2) immune checkpoint activation to suppress T cell responses, both on T cells and on AML cells themselves; (3) induction of T cell exhaustion; and (4) the induction of an immunosuppressive environment by increasing the numbers of regulatory T cells and other immunosuppressive populations in the bone marrow to inhibit effector and cytotoxic T cell activity. Here, HLA-C is linked to acute myeloid leukemia.