Accordingly, in a recent transcriptome analysis of AML cells from patients who relapsed following transplantation, a transcription factor complex consisting of IRF8, MYB, MEF2C, and MEIS1 was found to regulate MHC expression in AML, and combinatorial changes in their expression are essential for reduced MHC expression at relapse[34]. Here, IRF8 is linked to acute myeloid leukemia.