VEGFA and cancer: Extracellular vesicles serve a significant function in angiogenesis through the transport of various pro-angiogenic biomolecules, such as vascular endothelial growth factor (VEGF), microRNAs, and matrix metalloproteinases (MMPs), and also act as key agents in metastasis through their involvement in restructuring metastatic sites to support cancer cell colonization[29-31]; Extracellular vesicles have a key role as biomarkers in the cancer development through its components including proteins, nucleic acids and also from other biofluids [Table 1][32].