In a research study, the proteins Integrin Subunit Alpha 3 (ITGA3) and Integrin Subunit Beta 1 (ITGB1) were found in extracellular vesicles recovered from LNCaP and PC3 cells, released in the urine of PCa patients, both of them contributing to the diaspora and invasion of both tumors[109]. Here, ITGA3 is linked to posterior cortical atrophy.