CD8A and renal cell carcinoma: Wang et al. clustered TGCA RCC samples based on TME expression profiles and observed two different clusters: the first cluster, inflamed subtype (IS), was enriched for Treg cells, NK cells, Th cells, neutrophils, macrophages, eosinophils, B cells and CD8+ T cells, whereas the second cluster, not inflamed subtype (NIS), was enriched for angiogenesis, plasmacytoid DCs, and mast cells.