TAMs·M2-like TAMs correlate with worse prognosis in mRCCTregs·Anti-CTLA-4 mAbs are not effective in depleting Tregs expressing B7x immune checkpoint.MDSCs·Low MDSCs infiltration correlates with better outcomes with ICIsDCs·A specific subtype of DCs (NTLS-DCs) with immunosuppressive functions is dominant in ccRCC. Here, VTCN1 is linked to nonpapillary renal cell carcinoma.