Tumor-growth factor (TGF) and platelet-derived growth factor (PDGF) induce the transformation of tumor fibroblasts (FHNR) in cancer-associated fibroblasts (CAFs), which play a key role in tumor progression, producing pro-tumoral cytokines (e.g., IL-6, IL-8, TNF, IL-10). This evidence concerns the gene IL6 and neoplasm.