CD8A and nonpapillary renal cell carcinoma: However, ccRCC has the peculiarity of having a high degree of infiltration by exhausted CD8+ tumor-infiltrating lymphocytes (TILs), immunosuppressive cells such as M2-like tumor-associated macrophages (TAMs), regulatory T cells (Tregs), and myeloid-derived suppressor cells (MDSCs), which characterized a tumor microenvironment with immunosuppressive properties[10-12].