In a study examining the key inhibitory receptors (iR) expression on TILs and PBMCs of 35 patients with RCC, CD8+ T cells and non-Treg CD4+ cells highly expressed the inhibitory receptors PD-1, followed by LAG-3 and BTLA, whereas Tim-3 and CTLA-4 were less highly expressed. The gene discussed is CD8A; the disease is renal cell carcinoma.