Induction chemotherapy causes transient stress in BM, which results in the elevation of glutamine, glutamate, and aspartate with a concomitant increase in the expression of several glutamine transporters, such as Slc1a5, Slc38a1, Slc7a5, and Slc7a6, but no change in the enzymes that metabolize glutamine or glutamate, in residual AML cells[130,131]. This evidence concerns the gene SLC1A5 and acute myeloid leukemia.