IGF1 and acute myeloid leukemia: BM stromal cells exposed to AML-derived exosomes exhibit decreased expression of genes supporting normal hematopoiesis (CXCL12, KITL, IL-7, IGF1) and osteogenesis (OCN, Col1A1, IGF1) and increased expression of genes supporting AML growth (DKK1, IL-6, CCL3)[140].