BM stromal cells exposed to AML-derived exosomes exhibit decreased expression of genes supporting normal hematopoiesis (CXCL12, KITL, IL-7, IGF1) and osteogenesis (OCN, Col1A1, IGF1) and increased expression of genes supporting AML growth (DKK1, IL-6, CCL3)[140]. The gene discussed is COL1A1; the disease is acute myeloid leukemia.