ROC analysis for the classification of individual samples as belonging to early AD vs. control diagnostic categories [Figure 5K] showed that p181-Tau had the highest AUC (AUC = 0.832, P < 0.001), which was closely followed by GluR2 (AUC = 0.755, P < 0.001), proBDNF (AUC = 0.736, P < 0.001), GAP43 (AUC = 0.729, P < 0.001), NRGN (AUC = 0.716, P = 0.001), STXN1 (AUC = 0.709, P = 0.001), and PSD95 (AUC = 0.675, P = 0.005). This evidence concerns the gene DLG4 and Alzheimer disease.