SNCA and Parkinson disease: Rapid eye movement (REM) behavior disorder (RBD) is a potential prodromal biomarker to PD, it is reported RBD can cause alpha-synuclein deposition and neuroinflammation, and accelerating the progression of PD, besides, circadian rhythm injury can also contribute to abnormal inflammatory reaction under the pathogenesis of PD, glymphatic system dysfunction plays a pathogenic role in it (Scott-Massey et al., 2022).