PLAT and neoplasm: Moreover, it has been reported that another plasminogen activator, tissue type plasminogen activator (tPA) was significantly associated with tumor migration due to its activation of membrane receptors, like LRP1, Annexin2, and EGFR (Díaz et al., 2004; Ortiz-Zapater et al., 2007; Roda et al., 2009; Salama et al., 2019).