In addition, ICOSLG is expressed in a variety of tumors, such as glioblastoma (Schreiner et al., 2003), gastric cancer (Chen et al., 2003), colorectal cancer (Xiao et al., 2005), etc. The results of this study showed that ICOSLG was widely expressed in OSCC samples and was significantly expressed. Here, ICOSLG is linked to colorectal cancer.