ICOSLG and metastatic malignant neoplasm in the lymph nodes: According to our analysis, in OSCC, the high expression of ICOSLG in TCs and TILs was related to TNM stage and lymph node metastasis, and the OS, MFS and DFS of patients with high expression of ICOSLG in TCs and TILs were significantly shorter, indicating that the high expression of ICOSLG in OSCC may be a poor prognostic indicator.