ICOSLG and metastatic malignant neoplasm in the lymph nodes: The results showed that in OSCC patients, the expression of ICOSLG was not significantly correlated with gender, age, and differentiation, but the high expression of ICOSLG in TCs (ICOSLGTCs) and TILs (ICOSLGTILs) was associated with higher risk of lymph node metastasis and advanced TNM stage.