It has been reported that overexpression of PEG11/RTL1 leads to the development of hepatocellular carcinoma (HCC) in mice (Riordan et al., 2013) and that upregulation of PEG11/RTL1 occurs in a considerable proportion of human HCC samples (Riordan et al., 2013). The gene discussed is RTL1; the disease is hepatocellular carcinoma.