RTL4/SIRH11 (aka Zinc Finger CCHC Domain-Containint 16 (ZCCHC16) is implicated as a causative gene for autism spectrum disorders (ASD) (Lim et al., 2013) and Sirh11/Zcchc16 KO mice exhibit increased impulsivity and diminished spatial memory, probably due to low levels of noradrenaline in the frontal cortex (Irie et al., 2015). This evidence concerns the gene RTL4 and autism spectrum disorder.