Based on multivariate cox regression in two cohorts (Supplementary Table S5), PRDX1 was identified to be the independent prognostic predictor for HCC (TCGA-LIHC: p < 0.001, Hazard ratio = 1.715, 95%Confidence interval = 1.326–2.217; HCCDB18: p = 0.018, Hazard ratio = 1.787, 95%Confidence interval = 1.104–2.892). This evidence concerns the gene PRDX1 and hepatocellular carcinoma.