SORLA and sortilin are genetically associated with age-related neurodegeneration in Alzheimer’s disease (AD) (Rogaeva et al., 2007; Lambert et al., 2013; Bellenguez et al., 2022) and frontotemporal dementia (FTD) (Carrasquillo et al., 2010). Here, SORL1 is linked to frontotemporal dementia.