However, in view of the many genes found upregulated in Tau-depleted neuroblastoma cells in our study, the participation of other factors cannot be excluded and is further reinforced by the fact that we did not observe statistically significant changes in H3K27me3 marks at the IGFBP3 locus between Tau-KO and Tau expressing SH-SY5Y cells. This evidence concerns the gene IGFBP3 and neuroblastoma.