MAPT and tauopathy: With Tau being a microtubule-binding protein, a prevalent concept to explain the pathogenesis of tauopathies is that abnormal Tau modification e.g., phosphorylation and folding, contributes to Tau dissociation from microtubules, assembly into multimeric β-sheets, proteotoxicity, neuronal dysfunction and cell loss (Jeganathan et al., 2006; Ludolph et al., 2009).