The CCR7 gene, which contains HRE and is regulated by HIF complexes, has been suggested as a mediator of pro-metastatic effects of HIF-1α and HIF-2α in non-small cell lung cancer (Wilson, Burchell & Grimshaw, 2006; Li et al., 2009). The gene discussed is HIF1A; the disease is non-small cell lung carcinoma.