Indeed, it was reported that the lung fibroblast normally does not express or expresses a low level of ACHE, whereas the expression levels tend to be an opposite tendency in different cancer types, such as liver carcinoma and breast carcinoma (Richbart et al., 2021; Xi et al., 2015), demonstrating the heterogeneous biological status of ACHE among cancer types. This evidence concerns the gene ACHE and hepatocellular carcinoma.