Also, although the molecular mechanism through which P2X4R influences airway remodeling in allergic asthma remains largely unidentified, recent studies suggest that in mice with allergic asthma, the P2X4 receptor (P2X4R) plays a role in airway inflammation and airway remodeling by directly acting on the phenotype switching of BSMCs (Wang, et al., 2018). Here, P2RX4 is linked to allergic asthma.