Euphorbiasteroid (EPBS), a tricyclic terpenoid extracted from Euphorbia lathyrism L., inhibited the expression of EGFR, Wnt3a, and Fzd-1 in NSCLC cells and triggered the activation of GSK-3β, which in turn induced β-catenin degradation. Here, EGFR is linked to non-small cell lung carcinoma.