HNF4A and lung adenocarcinoma: A metastatic subpopulation isolated from node-derived lung adenocarcinoma cell lines has previously been shown to exhibit highly active Wnt/TCF signaling, and the Wnt/TCF target genes LEF1 and HOXB9 have been shown to promote LUAD cell colonization in the bone and brain (Nguyen et al., 2009).