EGFR and laryngotracheoesophageal cleft: In EGFR-overexpressing and-depleted LC cells, EPBS regulated the constitutive activation of the Wnt/β-catenin pathway, and the nuclear translocation of β-catenin was considerably decreased upon EPBS administration, suggesting that EPBS may be implemented alongside EGFR-TKIs in drug-resistant LC (Kim N. Y. et al., 2022).