WIF1 and colorectal cancer: Compared with colorectal cancer, activation of Wnt-mediated signaling takes place differently in LC, which is often associated with increased expression of Wnt pathway-activating effectors, such as Dvl and Wnt ligands, and downregulation of negative regulators, such as Axin and Wnt inhibitory factor-1 (WIF-1) (Mazieres et al., 2004; Mazieres et al., 2005; Tennis et al., 2007; Luo et al., 2018).